Immunotherapy for prostate cancer: Canadian working group presents the current status

In NATURE REVIEWS Urology, a Canadian working group presented the current status of immunotherapy for prostate cancer in a review article: "Potentiating prostate cancer immunotherapy with oncolytic viruses". They particularly emphasized the effect of oncolytic viruses. They also cited a case study conducted by us and mentioned the IOZK's therapy method with electrohyperthermia, Newcastle disease virus and dendritic cell-based vaccination. "In addition, a case study reports the development of prostate cancer-specific T-cell immune responses and long-term remission of metastatic castration-resistant prostate cancer after treatment with local hyperthermia, Newcastle disease virus and dendritic cell-based vaccination." (S. 10)

The article concludes optimistically: "Ultimately, the undermining of immunosuppression induced by oncolytic viruses promotes immunity to the tumor. Moreover, treatments with oncolytic viruses may enhance the effects of complementary cancer therapies [and] potentially lead to better patient outcomes than those that can be achieved by either treatment alone. The supportive immunological properties of oncolytic viruses, in addition to their oncolytic capabilities, are a promising approach for the next breakthrough in prostate cancer immunotherapy."

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