Honor for groundbreaking discovery in immunotherapy for Prof. Shimon Sakaguchi
Japanese researcher Prof. Shimon Sakaguchi from Osaka University is now being honored with the prestigious Paul Ehrlich Prize for his discovery of regulatory T cells, which he researched in the 1990s. Regulatory T cells are a subgroup of T cells whose task is to slow down and regulate the activation of the immune system. In doing so, they prevent the development of autoimmune diseases, but can also hinder the desired immune response against tumor cells. For this reason, they are also taken into account in IOZK immunotherapy.
Prof. Dr. Volker Schirrmacher and Stefaan van Gool, MD PhD, have already published various scientific papers on this topic, including:
Number D, Suri-Payer E, Schmitz-Winnenthal H, Bonertz A, Galindo L, Antolovich D, Koch M, Büchler M, Weitz J, Schirrmacher V, Beckhove P: Role of tumor endothelium in CD4+ CD25+ regulatory T cell infiltration of human pancreatic carcinoma. J Natl Cancer Inst. 2007 Aug 1;99(15):1188-99.
https://www.ncbi.nlm.nih.gov/pubmed/17652277
Maes W, Rosas GG, Verbinnen B, Boon L, De Vleeschouwer S, Ceuppens JL, Van Gool SW: DC vaccination with anti-CD25 treatment leads to long-term immunity against experimental glioma. Neuro Oncol. 2009 Oct;11(5):529-42.
https://www.ncbi.nlm.nih.gov/pubmed/19336528
Verbinnen B, Billiau AD, Vermeiren J, Galicia G, Bullens DM, Boon L, Cadot P, Hens G, Dewolf-Peeters C, Van Gool SW, Ceuppens JL: Contribution of regulatory T cells and effector T cell deletion in tolerance induction by costimulation blockade. J Immunol. 2008 Jul 15;181(2):1034-42.
