Case Report of a Patient with Breast Metastasis from Gastric Cancer Treated with Paclitaxel and Ramucirumab Plus Regional Hyperthermia

PMID: 30396986
Journal: Anticancer research (volume: 38, issue: 11, Anticancer Res. 2018 Nov;38(11):6561-6564)
Published: 2018-11-01

Lucchetti J, Formica V, Giuliano G, Coletta D, Gargano L, Morosetti D, Sileri P, Palmieri G, Roselli M


BACKGROUND: Breast metastases from extra mammary tumors are extremely rare.

CASE REPORT: Here we report the case of a 50-year-old female with histologically-confirmed gastric cancer metastasis to the breast who was adequately treated with loco-regional hyperthermia plus standard second-line chemotherapy (paclitaxel plus ramucirumab). The best response achieved was a relatively long disease stabilization.

CONCLUSION: Chemotherapy plus regional hyperthermia has been shown to have a synergistic antitumor effect and possible favorable immunomodulatory effects. Such an approach merits further investigation especially for the treatment of rare superficial metastatic sites.