Integrating oncolytic viruses in combination cancer immunotherapy

PMID: 29743717
Journal: Nature reviews. Immunology (volume: 18, issue: 8, Nat. Rev. Immunol. 2018 Aug;18(8):498-513)
Published: 2018-08-01

Bommareddy PK, Shettigar M, Kaufman HL


Oncolytic viruses can be usefully integrated into tumour immunotherapies, as they target multiple steps within the cancer-immunity cycle. Oncolytic viruses directly lyse tumour cells, leading to the release of soluble antigens, danger signals and type I interferons, which drive antitumour immunity. In addition, some oncolytic viruses can be engineered to express therapeutic genes or can functionally alter tumour-associated endothelial cells, further enhancing T cell recruitment into immune-excluded or immune-deserted tumour microenvironments. Oncolytic viruses can also utilize established tumours as an in situ source of neoantigen vaccination through cross-presentation, resulting in regression of distant, uninfected tumours. These features make oncolytic viruses attractive agents for combination strategies to optimize cancer immunotherapy.