Enhancement of antitumor response to sarcoma 45 in rats by combination of whole-body hyperthermia and interleukin-2

PMID: 15112583
Journal: Eksperimental’naia onkologiia (volume: 26, issue: 1, Eksp. Onkol. 2004 Mar;26(1):67-70)
Published: 2004-03-01

Authors:
Potapnev MP, Istomin YP, Ismail-zade RS, Zhavrid EA

ABSTRACT

AIM: To evaluate the summarized effect of hyperthermia and interleukin-2 (IL-2) administration on antitumor defense in tumor-bearing rats.

METHODS: Nonbred rats after subcutaneous inoculation of sarcoma 45 cells were treated with whole-body hyperthermia (WBH, +42.5 degrees C, 60 min) and interleukin-2 (IL-2, 10,000 U/kg of body weight). Parameters of tumor growth and survival of animals were monitored till day 33 after tumor cell inoculation.

RESULTS: Combined application of WBH and IL-2 at 5th day after tumor cell transplantation resulted in a delay of tumor growth and improvement of survival parameters in comparison with control group or animals that received separate treatment. Therapeutic efficacy of WBH combined with IL-2 was analogous to a single-dose chemotherapy with cyclophosphamide.

CONCLUSION: Combined application of WBH and IL-2 is the useful approach for cancer immunotherapy.