The oncolytic activity of Newcastle disease virus NDV-HUJ on chemoresistant primary melanoma cells is dependent on the proapoptotic activity of the inhibitor of apoptosis protein Livin. Patients with advanced melanoma usually do not benefit from conventional chemotherapy treatment. There is therefore a true need for a new kind of therapy for melanoma. One factor responsible for the poor prognosis of melanoma is the inhibitor of apoptosis protein (IAP) family member Livin. In this
Dec 2009 - J. Virol.; 84(1):1098-5514 [PMID:19864394]
[Lazar I] [Yaacov B] [Shiloach T] [Eliahoo E] [Kadouri L] [Lotem M] [Perlman R] [Zakay-Rones Z] [Panet A] [Ben-Yehuda D]